Browse the evidence

There is a strong need for multimodal therapeutic approaches to address obesity.

Therapists should implement diverse strategies to effectively manage obesity.

The combination of long-acting PYY analogs with a GLP-1 receptor agonist resulted in superior blood glucose lowering and greater body weight loss compared to GLP-1 alone.

Suggests a potential strategy for enhanced diabetes and obesity treatment.

Co-agonism of the glucagon and GLP-1 receptors improves glycemia in people with diabetes and obesity.

Practitioners may consider glucagon and GLP-1 receptor co-agonists as a treatment option for improving glycemia.

There are no indications of additional risk for people with HIV using liraglutide and semaglutide.

Liraglutide and semaglutide can be considered safe for use in HIV patients without additional risk.

Employment increased by 2.9 percentage points for the intensive lifestyle intervention (ILI) group relative to controls.

Implementing intensive lifestyle interventions may improve employment rates among individuals with type 2 diabetes.

An intensive lifestyle intervention was associated with higher levels of employment.

Healthcare providers should consider lifestyle interventions as a means to improve employment outcomes for patients with type 2 diabetes.

Patients exhibited initial physical functioning scores below the reference values yet demonstrated substantial physical recuperation by the 12-week mark following their ICU discharge in both groups.

Nutrition interventions may play a crucial role in recovery for post-ICU patients.

Continuous glucose monitoring can provide benefits when initiating GLP-1RA treatment.

Implementing continuous glucose monitoring can enhance the safety and effectiveness of GLP-1RA therapy.

Haemoglobin A1c (HbA1c) was significantly reduced at 12 months but not at 24 months.

Monitoring HbA1c levels can help assess the effectiveness of dietary interventions in T2DM.

The 7-year cardiovascular risk was 18.0% in the bariatric surgery group and 18.9% in the no-surgery group, with a risk difference of -0.9.

Bariatric surgery may not significantly reduce cardiovascular risk in this population.

The gut is a promising target for therapeutic interventions to achieve significant weight loss.

Practitioners should consider gut-targeted therapies as viable options for obesity treatment.

Current evidence indicates similar whole muscle hypertrophy between multi-joint (MJ) and single-joint (SJ) training.

Both MJ and SJ exercises can be effective for muscle growth.

There may be added benefit to combining SJ and MJ exercises for targeting individual aspects of a given muscle.

Combining SJ and MJ exercises may enhance muscle development.

Moderate-quality evidence revealed beneficial relationships between the intake of omega-6 fatty acids and cardiovascular disease (CVD) mortality, overall cancer mortality, and all-cause mortality.

Increasing omega-6 fatty acid intake may reduce risks of CVD and cancer.

Moderate-quality evidence suggested that seafood-derived omega-3 fatty acids were associated with reduced triglyceride levels, elevated high density lipoprotein cholesterol, and a decreased risk of coronary heart disease.

Encouraging seafood consumption may improve heart health and lipid profiles.

A significant global prevalence of inadequate omega-6 and seafood omega-3 fatty acid intakes exists, particularly in less-developed regions.

Efforts should be made to improve omega-6 and omega-3 intake in less-developed areas.

Longer rest interval lengths (RILs) have a small positive effect on repetition performance, allowing for more repetitions compared to shorter durations.

Practitioners should consider longer rest intervals to enhance performance in lower-body exercises.

Blood lactate levels are slightly higher with longer rest intervals.

Higher blood lactate levels with longer rest may indicate increased metabolic stress during training.

Exercise selection and rest interval length influence the rating of discomfort, with leg extensions producing less discomfort than back squats.

Selecting exercises with lower perceived discomfort may enhance training adherence.

Management strategies for weight regain include lifestyle interventions, pharmacotherapy, and revisional surgery.

A multidisciplinary approach incorporating these strategies is essential for effective long-term weight management.

High-intensity medical management leads to meaningful, though sometimes less substantial, weight loss and health improvements.

Practitioners should implement high-intensity medical management for patients preferring nonsurgical options.

The choice between metabolic surgery and high-intensity medical management should consider individual patient needs, health status, target weight loss, and personal preferences.

Practitioners should tailor treatment options based on individual patient circumstances.

Several anti-obesity drugs show significant reduction of fat mass, particularly visceral fat.

Practitioners can consider these drugs for effective fat loss, especially visceral fat.

GLP-1 receptor agonists suppress appetite and food reward to elicit rapid weight loss.

Practitioners can consider GLP-1 receptor agonists as effective options for weight loss.