Research
Molecular
Fifteen participants displayed robust benefits of moderate-volume training on muscle hypertrophy, associated with greater total RNA accumulation.
Identifying individuals who respond well to moderate training volume can help tailor training programs for better hypertrophy outcomes.
StrongSupportsmedium confidence
Fifteen participants displayed robust benefits of MOD on muscle hypertrophy. This was associated with greater accumulation of total RNA at Week 2 in MOD vs. LOW.
Why this rating
The study design allows for direct observation of individual responses.
Source
Benefits of higher resistance-training volume depends on ribosome biogenesis
Daniel Hammarström et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2019
DOI 10.1101/666347
cohort · n=34Cited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Moderate resistance training volume (3 sets per exercise) resulted in larger increases in muscle cross-sectional area (5.2% vs. 3.7%) and strength (3.4-7.7% difference) compared to low volume (1 set).Strong
- Ribosomal biogenesis regulates the dose-response relationship between training volume and muscle hypertrophy.Strong
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