Research
Metabolic adaptation
Exenatide combined with Metformin significantly reduced insulin resistance (HOMA-IR) by a mean difference of -0.9 (p < 0.001).
Practitioners may consider the combination of Exenatide and Metformin as an effective treatment for improving insulin resistance in women with PCOS.
StrongSupportsmedium confidence
Pooled analysis revealed that EX + MET significantly reduced HOMA-IR (mean difference [MD]: -0.9; p < 0.001).
Why this rating
Based on a systematic review and meta-analysis of five randomized controlled trials.
Source
Effects of Exenatide plus Metformin versus Metformin alone on insulin resistance in women with Polycystic Ovary Syndrome: A systematic review and meta‐analysis
Abd‐alrahman Al‐Qudah et al. · Journal of obstetrics and gynaecology research · 2025
Meta-analysisCited 2×
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