Research
Cellular
Collagen and free amino acid ingestion did not significantly increase myofibrillar protein synthesis rates in either rested or exercised legs.
Collagen and amino acid supplementation may not enhance muscle protein synthesis in healthy individuals post-exercise.
StrongRefutesmedium confidence
Collagen and free amino acid ingestion did not significantly increase myofibrillar protein synthesis rates in the rested or the exercised leg (P > 0.05).
Why this rating
Based on study design from abstract.
Source
The Effects of Ingesting a Single Bolus of Hydrolyzed Collagen versus Free Amino Acids on Muscle Connective Protein Synthesis Rates
Thorben Aussieker et al. · Medicine & Science in Sports & Exercise · 2025
DOI 10.1249/mss.0000000000003788
rct · n=45Cited 2×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Ingestion of a single bolus of hydrolyzed collagen or free amino acids substantially increases circulating amino acids concentrations, particularly glycine.Strong
- Collagen and free amino acid ingestion did not significantly increase muscle connective protein synthesis rates in either rested or exercised legs.Strong
Related findings · Cellular
- Athletes aiming to reduce fat mass and preserve FFM should consume protein intakes in the range of ∼1.8-2.7 g kg(-1) d(-1).Strong
- A minimum daily protein intake of ≥1.6 g/kg is necessary to observe significant improvements in muscle mass from whey protein supplementation.Strong
- Most athletes ideally need 1.2 to 2.0 grams/kg of body weight/day of protein, preferably split across 3-4 meals.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →