Research
Molecular
Higher Genetic Risk Score (GRS) relates to smaller year one change in waist circumference adjusted for body mass index (WCadjBMI) in lifestyle intervention arms.
Practitioners should consider genetic risk factors when designing weight loss interventions, as they may influence outcomes.
StrongSupportsmedium confidence
Among White participants, higher GRS related to smaller year one change in WCadjBMI in the lifestyle intervention arms, and thus predicted poorer response (p=0.009).
Why this rating
The study involves multiple lifestyle intervention trials, indicating a robust design.
Source
250-OR: Higher Genetic Risk Score Predicts Smaller Waist Circumference Change over One Year across Five Lifestyle Intervention Clinical Trials
Jeanne M. McCaffery et al. · Diabetes · 2021
DOI 10.2337/db21-250-or
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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