Research
Molecular
Each weighted risk allele in the GRS contributes to a 0.06 cm higher waist circumference at year 1 for individuals with an initial BMI of 34 and a year 1 reduction in BMI of 2.5.
Understanding the genetic contribution to waist circumference can help tailor interventions for individuals.
StrongSupportsmedium confidence
For a person with an initial BMI of 34 and a year 1 reduction in BMI of 2.5, each weighted risk allele in the GRS contributed to a 0.06 cm (SE=0.03) higher WC at year 1.
Why this rating
The study's design includes pooled results from multiple trials.
Source
250-OR: Higher Genetic Risk Score Predicts Smaller Waist Circumference Change over One Year across Five Lifestyle Intervention Clinical Trials
Jeanne M. McCaffery et al. · Diabetes · 2021
otherCited 1×
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