Research
Energy balance
No significant findings emerged in men and women separately, in the African-American subset, or for the 8-10 week outcomes.
Results may not be generalizable across all demographics, highlighting the need for tailored approaches.
StrongRefutesmedium confidence
No significant findings emerged in men and women separately, in the African-American subset, for the 8-10 week outcomes, or for the individuals SNPs after correcting for multiple comparisons.
Why this rating
The study's design includes multiple trials and diverse populations.
Source
250-OR: Higher Genetic Risk Score Predicts Smaller Waist Circumference Change over One Year across Five Lifestyle Intervention Clinical Trials
Jeanne M. McCaffery et al. · Diabetes · 2021
DOI 10.2337/db21-250-or
otherCited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Higher Genetic Risk Score (GRS) relates to smaller year one change in waist circumference adjusted for body mass index (WCadjBMI) in lifestyle intervention arms.Strong
- Each weighted risk allele in the GRS contributes to a 0.06 cm higher waist circumference at year 1 for individuals with an initial BMI of 34 and a year 1 reduction in BMI of 2.5.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →