Research
Metabolic adaptation
Individuals with insulin resistance (IR) have higher levels of de novo lipogenesis fatty acids (16:0: 22.9% vs 21.7% and 16:1n7: 1.8% vs 1.3%) and lower levels of omega-6 fatty acids (18:2n6: 30.8% vs 32.5%) compared to insulin sensitive (IS) individuals.
Practitioners should consider fatty acid profiles when assessing insulin resistance in overweight individuals.
StrongSupportsmedium confidence
Compared to the IS group, IR individuals had higher 16:0 (IR: 22.9% [22.2, 24.3] vs IS: 21.7% [20.2, 22.5]) and 16:1n7 (IR: 1.8% [1.4, 2.2] vs IS: 1.3% [1.1, 1.6]), and lower 18:2n6 (IR: 30.8% [27.8, 31.6] vs IS: 32.5% [30.0, 34.6]) levels at baseline.
Why this rating
Based on the study design involving measurements before and after dietary interventions.
Source
Abstract P220: Elevated De Novo Lipogenesis Fatty Acids and Lower Omega-6 Fatty Acids Are Associated With Markers of Insulin Resistance and Respond to Changes in Dietary Carbohydrate Intake in Overweight Individuals on Weight Loss Diets
Kristina Harris Jackson et al. · Circulation · 2018
cohort · n=61
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