Research
Metabolic adaptation
DNL fatty acid levels decrease on a low-carbohydrate (LC) diet and do not change on a low-fat (LF) diet.
Low-carbohydrate diets may be beneficial for reducing certain fatty acids associated with insulin resistance.
StrongSupportsmedium confidence
16:1n7 decreased on the LC diet and did not change on the LF diet (LC: -0.5% [-0.7, -0.3] vs LF: -0.1% [-0.3, 0.2]).
Why this rating
Based on the study design involving dietary interventions.
Source
Abstract P220: Elevated De Novo Lipogenesis Fatty Acids and Lower Omega-6 Fatty Acids Are Associated With Markers of Insulin Resistance and Respond to Changes in Dietary Carbohydrate Intake in Overweight Individuals on Weight Loss Diets
Kristina Harris Jackson et al. · Circulation · 2018
DOI 10.1161/circ.137.suppl_1.p220
cohort · n=61
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Individuals with insulin resistance (IR) have higher levels of de novo lipogenesis fatty acids (16:0: 22.9% vs 21.7% and 16:1n7: 1.8% vs 1.3%) and lower levels of omega-6 fatty acids (18:2n6: 30.8% vs 32.5%) compared to insulin sensitive (IS) individuals.Strong
- Changes in dietary carbohydrate intake correlate with changes in DNL fatty acid levels (16:1n7 directly and 18:2n6 indirectly).Strong
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