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At 15 months, total body weight loss (TBWL) was greater in mild versus severe IMS groups (14.8% vs. 11.0%, p = 0.015).
Clinicians should consider IMS severity when predicting weight loss outcomes with tirzepatide.
StrongSupportsmedium confidence
At 15 months, TBWL was greater in mild versus severe IMS groups (14.8% vs. 11.0%, p = 0.015).
Why this rating
Based on a retrospective analysis of a large cohort (717 adults).
Source
Leveraging the Individualized Metabolic Surgery Score to Predict Weight Loss with Tirzepatide in Adults with Type 2 Diabetes and Obesity
Regina Castaneda et al. · Diabetology · 2026
DOI 10.3390/diabetology7010010
cohort · n=717
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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