Research
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The proportion achieving ≥ 20% TBWL was nearly two-fold higher in mild versus severe IMS (27% vs. 14%, p = 0.03).
Higher IMS severity is associated with lower chances of achieving significant weight loss with tirzepatide.
StrongSupportsmedium confidence
The proportion achieving ≥ 20% TBWL was nearly two-fold higher in mild versus severe IMS (27% vs. 14%, p = 0.03).
Why this rating
Based on a retrospective analysis of a large cohort (717 adults).
Source
Leveraging the Individualized Metabolic Surgery Score to Predict Weight Loss with Tirzepatide in Adults with Type 2 Diabetes and Obesity
Regina Castaneda et al. · Diabetology · 2026
DOI 10.3390/diabetology7010010
cohort · n=717
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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