Research
Cellular
Tirzepatide is associated with lower mortality compared to both semaglutide and SGLT2 inhibitors.
Tirzepatide may offer a survival advantage for patients with type 2 diabetes.
StrongSupportsmedium confidence
Tirzepatide was associated with lower mortality (HR 0.72, 95% CI 0.58-0.90, p < 0.01; HR 0.29, 95% CI 0.23-0.37, p < 0.01).
Why this rating
Based on the large cohort study design.
Source
Target trial emulations for tirzepatide, semaglutide and SGLT2-inhibitors for dementia in patients with type 2 diabetes: Real world evidence from a retrospective cohort study
Alhena Younis et al. · Diabetes Research and Clinical Practice · 2026
DOI 10.1016/j.diabres.2026.113083
cohort · n=14462
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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