Research
Metabolic adaptation
Incretin polyagonists significantly reduced body weight compared to placebo (MD -11.47; 95% CI: -14.00 to -8.95).
Incretin polyagonists can be considered effective for weight management in obese patients.
StrongSupportsmedium confidence
Incretin polyagonists significantly reduced body weight compared to placebo (MD -11.47; 95% CI: -14.00 to -8.95).
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis
Zhi Hong Chan et al. · Cardiology in Review · 2026
DOI 10.1097/crd.0000000000001209
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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