Research
Cellular
The use of dual and triple agonists was associated with a higher risk of any adverse events (RR 1.13; 95% CI: 1.08-1.19).
Clinicians should be aware of the potential for increased adverse events when prescribing incretin polyagonists.
StrongSupportsmedium confidence
However, the use of dual and triple agonists was associated with a higher risk of any adverse events (AEs) (RR 1.13; 95% CI: 1.08-1.19).
Why this rating
Based on a systematic review and meta-analysis of randomized controlled trials.
Source
Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis
Zhi Hong Chan et al. · Cardiology in Review · 2026
DOI 10.1097/crd.0000000000001209
Meta-analysis
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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