Research
Metabolic adaptation
Obesity without metabolic abnormalities increases the risk of atherosclerotic cardiovascular disease (ASCVD) by 46% in men and 34% in women compared to those with normal BMI.
Practitioners should recognize that obesity, even without metabolic abnormalities, poses significant cardiovascular risks.
StrongSupportsmedium confidence
This prospective-cohort study of over 1.9 million person-years follow-up demonstrates that obesity without metabolic abnormality increases the risk of ASCVD by 46% in men and 34% in women respectively.
Why this rating
Based on study design from abstract.
Source
Obesity, metabolic health status, and adverse outcomes in men and women
R. Ananda et al. · American Journal of Preventive Cardiology · 2026
cohort · n=157159
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