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Protein supplementation resulted in a significant positive effect on muscle mass with a weighted mean difference of 0.47 kg (95% CI, 0.18-0.75 kg; P < .001).

Practitioners should consider recommending protein supplementation to enhance muscle mass in healthy individuals.

StrongSupportsmedium confidence
Protein but not amino acid supplementation resulted in significant positive effects on muscle mass (weighted mean difference, 0.47 kg; 95% confidence interval, 0.18-0.75 kg; P < .001).
Aliyu Tijani Jibril et al. · Nutrition Today · 2022

Why this rating

Based on data from 46 randomized controlled trials.

Source

Effects of Protein and Amino Acid Supplementation on Muscle Mass and Strength in a Healthy Population

Aliyu Tijani Jibril et al. · Nutrition Today · 2022

DOI 10.1097/nt.0000000000000543

Meta-analysis
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DOI resolved against Crossref · corpus check 2026-06-10

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