Research
Molecular
Insulin phosphorylates Akt and FoxO1, leading to reduced nuclear abundance of FoxO1 and repression of PGC-1alpha mRNA expression in healthy skeletal muscle.
Insulin's role in regulating PGC-1alpha expression is crucial for understanding metabolic responses in healthy muscle.
StrongSupportsmedium confidence
This is associated with an insulin-mediated repression of the mRNA expression PGC-1alpha and downstream genes associated with oxidative phosphorylation.
Why this rating
The study involves human skeletal muscle biopsy specimens and cultured myotubes.
Source
PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle
Robert J. Southgate et al. · The FASEB Journal · 2005
DOI 10.1096/fj.05-3993fje
otherCited 73×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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