Research
Molecular
In insulin-resistant muscle, insulin fails to phosphorylate Akt or FoxO1, resulting in the inability to repress PGC-1alpha expression.
Understanding the failure of insulin action in insulin-resistant states can inform treatment strategies.
StrongSupportsmedium confidence
In contrast, in muscle taken from insulin resistant humans or in palmitate-treated insulin resistant myotubes, neither Akt nor FoxO1 was phosphorylated by insulin, resulting in a failure for nuclear exclusion of FoxO1 total protein.
Why this rating
The study includes direct observations from human muscle samples.
Source
PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle
Robert J. Southgate et al. · The FASEB Journal · 2005
otherCited 73×
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