Research
Molecular
Insulin decreases the expression of genes involved in oxidative metabolism in healthy muscle through reduced FoxO1 phosphorylation and nuclear exclusion.
This finding highlights the importance of insulin in regulating oxidative metabolism in healthy individuals.
StrongSupportsmedium confidence
We conclude that insulin decreases the expression of genes involved in oxidative metabolism in healthy but not insulin resistant muscle.
Why this rating
The study is based on direct measurements in human muscle.
Source
PGC‐1α gene expression is down‐regulated by Akt‐mediated phosphorylation and nuclear exclusion of FoxO1 in insulin‐stimulated skeletal muscle
Robert J. Southgate et al. · The FASEB Journal · 2005
otherCited 73×
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