Research
Neural
Increasing levels of neurofilament light chain (NfL) are associated with worsening cognitive function and incident mild cognitive impairment or probable dementia.
Monitoring NfL levels may help in assessing cognitive decline in patients with T2D and obesity.
StrongSupportsmedium confidence
Increasing levels of NfL (β = -0.032 [SE, 0.013]; P = .01) ... were associated with worsening cognitive function and incident mild cognitive impairment or probable dementia.
Why this rating
Based on the longitudinal design of the study.
Source
Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity
Michelle M. Mielke et al. · JAMA Network Open · 2025
cohort · n=758Cited 22×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →