Research
Neural
Increasing levels of glial fibrillary acidic protein (GFAP) are associated with worsening cognitive function and incident mild cognitive impairment or probable dementia.
Tracking GFAP levels may provide insights into cognitive health in patients with T2D and obesity.
StrongSupportsmedium confidence
Increasing levels of GFAP (β = -0.087 [SE, 0.025]; P < .001) ... were associated with worsening cognitive function and incident mild cognitive impairment or probable dementia.
Why this rating
Based on the longitudinal design of the study.
Source
Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity
Michelle M. Mielke et al. · JAMA Network Open · 2025
cohort · n=758Cited 22×
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