Research
Neural
The intensive lifestyle intervention (ILI) did not result in preserved cognitive function or slower rates of cognitive decline in individuals with type 2 diabetes and overweight/obesity.
Practitioners should be cautious in expecting cognitive benefits from lifestyle interventions in this population.
StrongRefutesmedium confidence
The ILI did not result in preserved cognitive function or slower rates of cognitive decline in this cohort of individuals who had T2D and were overweight or obese at baseline.
Why this rating
Based on a randomized clinical trial with a large cohort.
Source
Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus
Kathleen M. Hayden et al. · Dementia and Geriatric Cognitive Disorders · 2021
DOI 10.1159/000517160
rct · n=3938Cited 15×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Participants with a baseline history of cardiovascular disease (CVD) who were randomized to the ILI performed significantly worse on the Stroop Color Word Test than those in the diabetes support and education (DSE) arm.Strong
- There were no differences in the rate of cognitive decline by intervention arm overall.Strong
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