Research
Neural
There were no differences in the rate of cognitive decline by intervention arm overall.
Interventions may not impact cognitive decline rates, suggesting a need for alternative strategies.
StrongRefutesmedium confidence
Overall, there were no differences in the rate of cognitive decline by intervention arm.
Why this rating
Based on a large randomized clinical trial.
Source
Legacy of a 10-Year Multidomain Lifestyle Intervention on the Cognitive Trajectories of Individuals with Overweight/Obesity and Type 2 Diabetes Mellitus
Kathleen M. Hayden et al. · Dementia and Geriatric Cognitive Disorders · 2021
DOI 10.1159/000517160
rct · n=3938Cited 15×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- The intensive lifestyle intervention (ILI) did not result in preserved cognitive function or slower rates of cognitive decline in individuals with type 2 diabetes and overweight/obesity.Strong
- Participants with a baseline history of cardiovascular disease (CVD) who were randomized to the ILI performed significantly worse on the Stroop Color Word Test than those in the diabetes support and education (DSE) arm.Strong
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