Research
Cellular
A single bout of low-intensity cycling with BFR is insufficient to induce intracellular stress responses necessary to activate skeletal muscle autophagy signaling.
Practitioners should note that low-intensity cycling with BFR may not effectively stimulate autophagy in inactive individuals.
StrongRefutesmedium confidence
We conclude that a single bout of low-intensity cycling with BFR is insufficient to induce intracellular 'stress' responses (e.g., high rates of substrate turnover, local hypoxia) necessary to activate skeletal muscle autophagy signaling.
Why this rating
Based on randomized cross-over design.
Source
Autophagy and Metabolic Signaling in Human Skeletal Muscle after Acute Low-Intensity Exercise Cycling with Blood Flow Restriction.
Guilherme Defante Telles et al. · Anais do Congresso de Iniciação Científica da Unicamp · 2016
DOI 10.19146/pibic-2016-51580
cross-sectional · n=9
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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