Research
Molecular
A one standard deviation higher polygenic score (PS) related to a smaller one-year change in waist circumference adjusted for body mass index (WCadjBMI) in the lifestyle intervention arms at year 1, predicting poorer response among White participants overall.
Practitioners should consider genetic factors when assessing weight loss responses in individuals.
StrongSupportsmedium confidence
One standard deviation higher PS related to smaller one-year change in WCadjBMI in the lifestyle intervention arms at year 1.
Why this rating
Based on the analysis of multiple lifestyle intervention trials.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
DOI 10.2337/figshare.17890715
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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