Research
Molecular
The effect of polygenic risk on change in WCadjBMI with lifestyle intervention is small and not of sufficient magnitude to be clinically significant.
Genetic factors may play a role in weight loss, but their impact may not be significant enough to warrant changes in intervention strategies.
StrongQualifiesmedium confidence
These results indicate that polygenic risk relates to change in WCadjBMI with lifestyle intervention but the effects are small and not of sufficient magnitude to be clinically significant.
Why this rating
Based on the analysis of multiple lifestyle intervention trials.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
DOI 10.2337/figshare.17890715
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A one standard deviation higher polygenic score (PS) related to a smaller one-year change in waist circumference adjusted for body mass index (WCadjBMI) in the lifestyle intervention arms at year 1, predicting poorer response among White participants overall.Strong
- No significant findings emerged in White women, African American men, or for the 8-10 week outcomes regarding WCadjBMI or WHRadjBMI.Strong
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