Research
Molecular
The effect of polygenic risk on change in WCadjBMI with lifestyle intervention is small and not of sufficient magnitude to be clinically significant.
Genetic factors may play a role in weight loss, but their impact may not be significant enough to warrant changes in intervention strategies.
StrongQualifiesmedium confidence
These results indicate that polygenic risk relates to change in WCadjBMI with lifestyle intervention but the effects are small and not of sufficient magnitude to be clinically significant.
Why this rating
Based on the analysis of multiple lifestyle intervention trials.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
other
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