Research
Energy balance
No significant findings emerged in White women, African American men, or for the 8-10 week outcomes regarding WCadjBMI or WHRadjBMI.
Results may not be generalizable to all demographic groups, indicating the need for tailored approaches in interventions.
StrongRefutesmedium confidence
No significant findings emerged in White women, African American men, for the 8-10 week outcomes or for WHRadjBMI.
Why this rating
Based on the analysis of multiple lifestyle intervention trials.
Source
Genetic Predictors of Change in Waist Circumference and Waist-To-Hip Ratio with Lifestyle Intervention: the Trans-NIH consortium for Genetics of Weight Loss Response to Lifestyle Intervention
Jeanne M. McCaffery et al. · 2022
DOI 10.2337/figshare.17890715
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- A one standard deviation higher polygenic score (PS) related to a smaller one-year change in waist circumference adjusted for body mass index (WCadjBMI) in the lifestyle intervention arms at year 1, predicting poorer response among White participants overall.Strong
- The effect of polygenic risk on change in WCadjBMI with lifestyle intervention is small and not of sufficient magnitude to be clinically significant.Strong
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →