Research
Cellular
GLP-1-based therapies can lead to significant aesthetic issues in the face and neck, including midface volume loss and increased skin laxity.
Practitioners should be aware of these aesthetic concerns when treating patients on GLP-1 therapies.
StrongSupportsmedium confidence
However, there can be significant sequelae with regard to the aesthetics of the face and neck, including midface volume loss; temple, infraorbital, and submalar hollowing; increased skin laxity; accentuation of wrinkles and folds; and worsened skin quality.
Why this rating
Based on expert opinion and experience-based guidance.
Source
Nonsurgical Aesthetic Treatment of the Face and Neck in GLP-1 Receptor Agonist Weight Loss Patients: Experience-Based Considerations
Amir Moradi et al. · Aesthetic Surgery Journal Open Forum · 2026
DOI 10.1093/asjof/ojag011
otherCited 3×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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