Mixed
Higher scores on the Dietary Index for Gut Microbiota (DI-GM), specifically driven by beneficial components, are associated with significantly reduced all-cause and cardiovascular mortality in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0-3.
For individuals with early-stage metabolic or kidney risks, prioritizing foods known to support gut health—such as fiber, fermented dairy, whole grains, and specific fruits/vegetables—may lower the risk of death from heart or other causes. This benefit appears distinct from just general dietary quality, suggesting specific gut-microbiome interactions are key.
Elevated DI-GM dietary scores, particularly those emphasizing food components beneficial to the gut microbiota, demonstrate protective associations against both all-cause and cardiovascular mortality in individuals with CKM syndrome in stages 0–3.
Why this rating
Large prospective cohort (n=7884), rigorous statistical adjustments, but observational design limits causal inference.
Source
Dietary Index for Gut Microbiota and Risk of All-Cause and Cardiovascular Mortality Across Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study
Yifei Wang et al. · Reviews in Cardiovascular Medicine · 2026
DOI 10.31083/rcm45493
More from this paper
- The protective effect of beneficial dietary components on all-cause mortality is partially mediated by a reduction in systemic inflammation, as measured by the Systemic Inflammation Index (SII).Good
- High unfavorable dietary components (processed meats, red meats, refined grains, high-fat patterns) are associated with increased all-cause mortality but show no significant association with cardiovascular mortality after full adjustment.Good
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →