Mixed
In patients with type 2 diabetes and recent acute coronary syndrome, a body weight loss of 5% or more is independently associated with a significantly higher risk of all-cause mortality and cardiovascular events.
If you have diabetes and a history of heart issues, losing more than 5% of your body weight without trying is a medical emergency. It often signals worsening heart failure, kidney disease, or other serious conditions. Do not view this weight loss as a success; consult your doctor immediately to investigate the cause.
A weight loss ≥ 5% was independently associated with a higher risk of subsequent adverse outcomes, including all-cause mortality: adjusted HR (95% CI) 1.79 (1.33–2.42), P < 0.001.
Why this rating
Derived from a large, randomized clinical trial (EXAMINE) with time-updated Cox models, though the analysis is observational regarding the weight change itself.
Source
Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial
João Pedro Ferreira et al. · Cardiovascular Diabetology · 2021
DOI 10.1186/s12933-021-01382-8
More from this paper
- In patients with type 2 diabetes and recent acute coronary syndrome, a body weight gain of 5% or more is independently associated with an increased risk of cardiovascular mortality or heart failure hospitalization.Good
- In patients with type 2 diabetes and recent acute coronary syndrome, a higher baseline Body Mass Index (BMI > 30 kg/m2) is associated with a lower risk of primary cardiovascular outcomes compared to those with a BMI of 26-30 kg/m2.Good
Related findings · Mixed
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- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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