Mixed
In patients with type 2 diabetes and recent acute coronary syndrome, a higher baseline Body Mass Index (BMI > 30 kg/m2) is associated with a lower risk of primary cardiovascular outcomes compared to those with a BMI of 26-30 kg/m2.
If you have diabetes and recent heart issues, having a higher BMI (over 30) might actually protect you from cardiovascular events compared to being 'normal' weight. Do not attempt aggressive weight loss unless advised by your doctor, as maintaining your current weight may be beneficial for your heart.
Patients with a BMI > 30 kg/m2 (including those with a BMI > 35 kg/m2) had a lower risk of a primary outcome event: adjusted HR (95% CI) 0.75 (0.60–0.96), P = 0.020 for patients with a BMI between 31 and 35 kg/m2 and 0.61 (0.41–0.92), P = 0.017 for patients with a BMI > 35 kg/m2.
Why this rating
Derived from the same large RCT (EXAMINE) with time-updated Cox models.
Source
Body weight changes in patients with type 2 diabetes and a recent acute coronary syndrome: an analysis from the EXAMINE trial
João Pedro Ferreira et al. · Cardiovascular Diabetology · 2021
DOI 10.1186/s12933-021-01382-8
More from this paper
- In patients with type 2 diabetes and recent acute coronary syndrome, a body weight loss of 5% or more is independently associated with a significantly higher risk of all-cause mortality and cardiovascular events.Good
- In patients with type 2 diabetes and recent acute coronary syndrome, a body weight gain of 5% or more is independently associated with an increased risk of cardiovascular mortality or heart failure hospitalization.Good
Related findings · Mixed
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