Mixed
Prior endurance training history does not blunt the acute upregulation of metabolic genes (PGC-1α, PDK-4, VEGF) in skeletal muscle following a single bout of endurance exercise.
If you are a strength athlete, don't skip cardio thinking it won't work for you. Your muscles will still respond to endurance exercise by increasing the mRNA for key metabolic and blood vessel genes, just as an endurance athlete's would.
Notwithstanding these observations, such conditions did not preclude an endurance exercise-induced increase in 'metabolic genes' in this subject population.
Why this rating
Controlled crossover design with trained athletes, but limited to a single time point (3h) and small sample size (n=13).
Source
Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes
Vernon G. Coffey et al. · American Journal of Physiology-Endocrinology and Metabolism · 2005
DOI 10.1152/ajpendo.00299.2005
More from this paper
- Prior strength training history significantly alters the acute myogenic gene response (MyoD, myogenin) to endurance exercise compared to endurance-trained individuals.Good
- Prior endurance training history enhances the acute myogenic gene response (MyoD increase, MAFbx/myostatin decrease) to resistance exercise compared to strength-trained individuals.Good
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