Mixed
Prior endurance training history enhances the acute myogenic gene response (MyoD increase, MAFbx/myostatin decrease) to resistance exercise compared to strength-trained individuals.
If you are an endurance athlete, don't worry that your cardio prevents you from building muscle. A single resistance workout triggers strong muscle-building gene signals (MyoD) and reduces muscle-breakdown signals (myostatin/MAFbx) in your muscles, even more so than in strength athletes.
In ET subjects, MyoD increased (~0.7-fold, NS), but MAFbx (~0.7-fold; NS) and myostatin (~0.6-fold, NS) both decreased after resistance exercise. In ST subjects, the mRNA abundance of the myogenic genes under investigation was not significantly altered by a single bout of resistance exercise.
Why this rating
Clear difference in response magnitude and direction between groups.
Source
Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes
Vernon G. Coffey et al. · American Journal of Physiology-Endocrinology and Metabolism · 2005
DOI 10.1152/ajpendo.00299.2005
More from this paper
- Prior endurance training history does not blunt the acute upregulation of metabolic genes (PGC-1α, PDK-4, VEGF) in skeletal muscle following a single bout of endurance exercise.Good
- Prior strength training history significantly alters the acute myogenic gene response (MyoD, myogenin) to endurance exercise compared to endurance-trained individuals.Good
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