Mixed
Prior strength training history significantly alters the acute myogenic gene response (MyoD, myogenin) to endurance exercise compared to endurance-trained individuals.
If you are a strength athlete, your muscles react to cardio differently than an endurance athlete's. You may not see the same 'muscle-building' gene signals (MyoD/myogenin) during cardio that an endurance runner does. This doesn't mean cardio is bad for you, but your body is prioritizing different adaptations.
Cycling exercise produced diverse responses between ET and ST subjects for the myogenic regulatory factors MyoD and myogenin... There was an increase in both MyoD (~3-fold) and myogenin mRNA (~0.9-fold) in ET subjects after cycling. In contrast, cycling decreased MyoD (~0.4-fold) and myogenin (~0.4-fold) in ST subjects.
Why this rating
Clear divergence in response between groups, but mechanism for ST suppression is described as 'elusive'.
Source
Interaction of contractile activity and training history on mRNA abundance in skeletal muscle from trained athletes
Vernon G. Coffey et al. · American Journal of Physiology-Endocrinology and Metabolism · 2005
DOI 10.1152/ajpendo.00299.2005
More from this paper
- Prior endurance training history does not blunt the acute upregulation of metabolic genes (PGC-1α, PDK-4, VEGF) in skeletal muscle following a single bout of endurance exercise.Good
- Prior endurance training history enhances the acute myogenic gene response (MyoD increase, MAFbx/myostatin decrease) to resistance exercise compared to strength-trained individuals.Good
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