Mixed
Higher Dietary Inflammatory Index (DII) scores are independently associated with an increased risk of Coronary Heart Disease (CHD), with a 1-unit increase in DII corresponding to an odds ratio of 1.049 for CHD after adjusting for confounders.
Focus on reducing pro-inflammatory foods and increasing anti-inflammatory ones, specifically paying attention to carbohydrate quality, ensuring adequate Vitamin C and Iron intake. While you don't need to calculate a complex index, these specific nutrients appear to drive the inflammatory response linked to heart disease risk.
After adjusting for potential confounders, logistic regression analysis revealed that DII independently associated with CHD [OR: 1.049 (1.012–1.087), p = 0.008].
Why this rating
Large sample size (n=43,842) and long duration (1999-2018) but cross-sectional design limits causal inference.
Source
The relationship between dietary inflammatory index in adults and coronary heart disease: from NHANES 1999–2018
Xu Hong et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1564580
More from this paper
- The association between Dietary Inflammatory Index (DII) and Coronary Heart Disease (CHD) is mediated by metabolic and lipid indicators, specifically Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Body Mass Index (BMI), Waist-to-Height Ratio (WHtR), High-Density Lipoprotein (HDL), and Glomerular Filtration Rate (GFR).Moderate
- The adverse impact of Dietary Inflammatory Index (DII) on Coronary Heart Disease (CHD) is more pronounced in individuals aged <75 years, females, those with low cholesterol levels, and those with low Framingham risk scores.Moderate
- Among dietary components contributing to the Dietary Inflammatory Index (DII), carbohydrate, vitamin C, and iron have the greatest impact on Coronary Heart Disease (CHD) risk, while vitamin D, alcohol, and monounsaturated fatty acids have the least impact.Moderate
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