Research
Mixed
The association between Dietary Inflammatory Index (DII) and Coronary Heart Disease (CHD) is mediated by metabolic and lipid indicators, specifically Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Body Mass Index (BMI), Waist-to-Height Ratio (WHtR), High-Density Lipoprotein (HDL), and Glomerular Filtration Rate (GFR).
Managing weight, blood sugar, and cholesterol through diet can help mitigate the heart disease risk associated with inflammatory diets. Specifically, improving HDL and reducing visceral fat are key steps.
ModerateSupportsMEDIUM confidence
Triglyceride-glucose index, visceral adiposity index, body mass index, waist-to-height ratio, high-density lipoprotein, and glomerular filtration rate (all p < 0.05) may mediate the relationship between DII and CHD.
Why this rating
Mediation analysis is performed, but cross-sectional nature limits causal confirmation of the mediation pathway.
Source
The relationship between dietary inflammatory index in adults and coronary heart disease: from NHANES 1999–2018
Xu Hong et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1564580
cross_sectional · n=43842Cited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Higher Dietary Inflammatory Index (DII) scores are independently associated with an increased risk of Coronary Heart Disease (CHD), with a 1-unit increase in DII corresponding to an odds ratio of 1.049 for CHD after adjusting for confounders.Moderate
- The adverse impact of Dietary Inflammatory Index (DII) on Coronary Heart Disease (CHD) is more pronounced in individuals aged <75 years, females, those with low cholesterol levels, and those with low Framingham risk scores.Moderate
- Among dietary components contributing to the Dietary Inflammatory Index (DII), carbohydrate, vitamin C, and iron have the greatest impact on Coronary Heart Disease (CHD) risk, while vitamin D, alcohol, and monounsaturated fatty acids have the least impact.Moderate
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →