Research
Mixed
The adverse impact of Dietary Inflammatory Index (DII) on Coronary Heart Disease (CHD) is more pronounced in individuals aged <75 years, females, those with low cholesterol levels, and those with low Framingham risk scores.
If you are young, female, or have low traditional heart disease risk, your diet's inflammatory potential may have a disproportionately larger impact on your heart health compared to high-risk individuals.
ModerateQualifiesMEDIUM confidence
Subgroup analyses showed that DII was more sensitive in participants aged <75 years (p < 0.001), females (p = 0.028), those with low cholesterol levels (p = 0.004), and individuals with low Framingham risk scores (p = 0.005).
Why this rating
Statistically significant interaction p-values, but cross-sectional design limits causal inference.
Source
The relationship between dietary inflammatory index in adults and coronary heart disease: from NHANES 1999–2018
Xu Hong et al. · Frontiers in Nutrition · 2025
DOI 10.3389/fnut.2025.1564580
cross_sectional · n=43842Cited 10×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Higher Dietary Inflammatory Index (DII) scores are independently associated with an increased risk of Coronary Heart Disease (CHD), with a 1-unit increase in DII corresponding to an odds ratio of 1.049 for CHD after adjusting for confounders.Moderate
- The association between Dietary Inflammatory Index (DII) and Coronary Heart Disease (CHD) is mediated by metabolic and lipid indicators, specifically Triglyceride-Glucose (TyG) index, Visceral Adiposity Index (VAI), Body Mass Index (BMI), Waist-to-Height Ratio (WHtR), High-Density Lipoprotein (HDL), and Glomerular Filtration Rate (GFR).Moderate
- Among dietary components contributing to the Dietary Inflammatory Index (DII), carbohydrate, vitamin C, and iron have the greatest impact on Coronary Heart Disease (CHD) risk, while vitamin D, alcohol, and monounsaturated fatty acids have the least impact.Moderate
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