Energy balance
SGLT-2 inhibitors and DPP-4 inhibitors produce modest or neutral weight loss effects, respectively, making them less effective for weight management compared to GLP-1 agonists.
SGLT-2 inhibitors offer modest weight loss (3-5%), while DPP-4 inhibitors are generally weight-neutral or have mild effects. They are less effective for weight management than GLP-1 agonists. SGLT-2 inhibitors work by excreting glucose in urine, but compensatory mechanisms limit weight loss. DPP-4 inhibitors are better suited for glycemic control without significant weight impact.
metformin and sodium-dependent glucose cotransporter proteins-2 (SGLT-2) inhibitors have modest weight loss effects... Dipeptidyl peptidase 4 (DPP-4) inhibitors showed a neutral or mild weight loss effect.
Why this rating
Based on review of multiple clinical trials and meta-analyses.
Source
A Comprehensive Review on Weight Loss Associated with Anti-Diabetic Medications
Fatma Haddad et al. · Life · 2023
DOI 10.3390/life13041012
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