Mixed
Phenotype-tailored lifestyle interventions (PLI) result in significantly greater weight loss (-7.4 kg) compared to standard lifestyle interventions (SLI, -4.3 kg) in adults with obesity over a 12-week period.
To maximize weight loss, identify your specific obesity phenotype (e.g., abnormal satiation, emotional eating, or low energy expenditure) through professional assessment. Then, follow a tailored plan that combines a 500-calorie daily deficit with specific behavioral or exercise strategies (like pre-meal protein or HIIT) designed for your phenotype, rather than a generic diet.
The weight loss was −7.4 kg (95%CI, −8.8, −6.0) with PLI vs. −4.3 kg (95%CI, −5.8, −2.7) with SLI (difference, −3.1 kg [95%CI, −5.1 to −1.1]; P = 0.004).
Why this rating
Non-randomized, single-center, proof-of-concept study with potential selection bias due to phase-based assignment.
Source
Phenotype tailored lifestyle intervention on weight loss and cardiometabolic risk factors in adults with obesity: a single-centre, non-randomised, proof-of-concept study
Lizeth Cifuentes et al. · EClinicalMedicine · 2023
DOI 10.1016/j.eclinm.2023.101923
More from this paper
- Phenotype-tailored interventions improve specific cardiometabolic risk factors, including waist circumference and triglycerides, more effectively than standard lifestyle interventions.Moderate
- Phenotype-tailored interventions preserve lean mass percentage and resting energy expenditure (REE) better than standard lifestyle interventions.Moderate
Related findings · Mixed
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