Energy balance
Phenotype-tailored interventions improve specific cardiometabolic risk factors, including waist circumference and triglycerides, more effectively than standard lifestyle interventions.
Focus on reducing waist circumference and triglycerides by adhering to a phenotype-tailored plan that ensures a consistent caloric deficit and appropriate physical activity, as this approach has been shown to improve these specific risk factors more than standard advice.
The PLI group had a significant reduction in waist circumference at week 12 compared SLI group (−7.9 cm [95%CI −9.8, −6.0] vs. −4.1 cm [95%CI −6.1, −2.0]; P < 0.001)... At week 12, fasting triglycerides were significantly lower in the PLI group (−19 mg/dl [95%CI −31, −7]) compared to the SLI group (8 mg/dl [95%CI −6, 22], p = 0.002).
Why this rating
Non-randomized design limits causal inference for secondary endpoints.
Source
Phenotype tailored lifestyle intervention on weight loss and cardiometabolic risk factors in adults with obesity: a single-centre, non-randomised, proof-of-concept study
Lizeth Cifuentes et al. · EClinicalMedicine · 2023
DOI 10.1016/j.eclinm.2023.101923
More from this paper
- Phenotype-tailored lifestyle interventions (PLI) result in significantly greater weight loss (-7.4 kg) compared to standard lifestyle interventions (SLI, -4.3 kg) in adults with obesity over a 12-week period.Moderate
- Phenotype-tailored interventions preserve lean mass percentage and resting energy expenditure (REE) better than standard lifestyle interventions.Moderate
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