Research
Energy balance
Phenotype-tailored interventions preserve lean mass percentage and resting energy expenditure (REE) better than standard lifestyle interventions.
To maintain muscle and metabolic rate during weight loss, follow a phenotype-tailored plan that includes specific exercise (like HIIT for low REE) and protein timing, as these strategies help preserve lean mass better than standard advice.
ModerateSupportsMEDIUM confidence
Lean mass percentage was significantly increased (p = 0.006) in the PLI group (2.9% [95%CI 2.1, 3.7) compared to the SLI group (1.7% [95%CI 1.2, 2.2]). ... measured REE at 12 weeks showed a significantly smaller reduction from baseline in the PLI group compared to the SLI group (adjusted difference 4.4% [95%CI 0.5%, 8.5%], p = 0.034).
Why this rating
Non-randomized design.
Source
Phenotype tailored lifestyle intervention on weight loss and cardiometabolic risk factors in adults with obesity: a single-centre, non-randomised, proof-of-concept study
Lizeth Cifuentes et al. · EClinicalMedicine · 2023
DOI 10.1016/j.eclinm.2023.101923
clinical_trial · n=165Cited 54×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Phenotype-tailored lifestyle interventions (PLI) result in significantly greater weight loss (-7.4 kg) compared to standard lifestyle interventions (SLI, -4.3 kg) in adults with obesity over a 12-week period.Moderate
- Phenotype-tailored interventions improve specific cardiometabolic risk factors, including waist circumference and triglycerides, more effectively than standard lifestyle interventions.Moderate
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