Mixed
Higher circulating levels of the trans-fatty acid isomer trans/trans-18:2 (t/t-18:2) are associated with significantly increased risks of total mortality, cardiovascular disease (CVD) mortality, and total coronary heart disease (CHD).
Avoid foods containing partially hydrogenated oils, as they are the primary source of the trans fatty acid isomer t/t-18:2, which is linked to higher risks of heart disease and death. While natural sources of trans fats exist (like in some dairy/meat), this study highlights that the industrial isomer t/t-18:2 is the most harmful. For older adults, minimizing industrial trans fats is a key step for longevity.
circulating t/t-18:2 was associated with higher total mortality (extreme quintile hazard ratio (HR)=1.23, 95% CI=1.04 to 1.44, P-trend=0.01), CVD mortality (HR=1.40, 95% CI=1.05 to 1.86, P-trend=0.02), and total CHD (HR=1.39, 95% CI=1.06 to 1.83, P-trend=0.01).
Why this rating
Large prospective cohort (n=2742), long follow-up (31,494 person-years), objective biomarker measurement, and rigorous adjustment for confounders.
Source
Plasma Phospholipid <i>Trans</i> ‐Fatty Acids Levels, Cardiovascular Diseases, and Total Mortality: The Cardiovascular Health Study
Qianyi Wang et al. · Journal of the American Heart Association · 2014
DOI 10.1161/jaha.114.000914
More from this paper
- Higher circulating levels of the trans-fatty acid isomer trans/cis-18:2 (t/c-18:2) are associated with increased total mortality and coronary heart disease (CHD) incidence, but only after mutual adjustment for other TFA subtypes.Good
- Circulating levels of trans-16:1n9 and total trans-18:1 are not significantly associated with total mortality or cardiovascular disease mortality in older adults.Good
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