Mixed
Higher circulating levels of the trans-fatty acid isomer trans/cis-18:2 (t/c-18:2) are associated with increased total mortality and coronary heart disease (CHD) incidence, but only after mutual adjustment for other TFA subtypes.
The isomer t/c-18:2 is linked to higher heart disease risk, particularly when other trans fats are accounted for. Since industrial trans fats (partially hydrogenated oils) are a major source of various trans isomers, avoiding these processed foods helps minimize exposure to potentially harmful isomers like t/c-18:2.
t/c-18:2 was positively related to total mortality (HR=1.19, P-trend=0.05), total CHD (HR=1.67, P-trend=0.002), and nonfatal CHD (HR=2.06, P-trend=0.002) after mutual adjustment; these associations were insignificant without mutual adjustment.
Why this rating
Same high-quality cohort design as N1, but the finding is sensitive to model specification (mutual adjustment).
Source
Plasma Phospholipid <i>Trans</i> ‐Fatty Acids Levels, Cardiovascular Diseases, and Total Mortality: The Cardiovascular Health Study
Qianyi Wang et al. · Journal of the American Heart Association · 2014
DOI 10.1161/jaha.114.000914
More from this paper
- Higher circulating levels of the trans-fatty acid isomer trans/trans-18:2 (t/t-18:2) are associated with significantly increased risks of total mortality, cardiovascular disease (CVD) mortality, and total coronary heart disease (CHD).Good
- Circulating levels of trans-16:1n9 and total trans-18:1 are not significantly associated with total mortality or cardiovascular disease mortality in older adults.Good
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