Research
Energy balance
Weight gain after a type 2 diabetes diagnosis is associated with an increased risk of cardiovascular disease events and all-cause mortality.
Avoiding weight gain after a type 2 diabetes diagnosis is important for reducing the risk of heart disease and death. Maintaining a stable weight is associated with better cardiovascular outcomes than gaining weight.
GoodSupportsMEDIUM confidence
Weight gain (vs no change) was associated with higher hazard of CVD events (HRs [95% CIs] ranged from 1.13 [1.00, 1.29] to 1.63 [1.11, 2.39]) and all-cause mortality (HRs [95% CIs] ranged from 1.26 [1.12, 1.41] to 1.57 [1.33, 1.85]).
Why this rating
Based on multiple observational studies with consistent findings, though with moderate risk of bias.
Source
Effects of Weight Loss and Interaction with Physical Activity on Risks of Cardiovascular Outcomes in Individuals with Type 2 Diabetes
Claudia R.L. Cardoso et al. · Endocrinology and Metabolism · 2023
DOI 10.3803/enm.2023.1690
Meta-analysis · 17 studiesCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- In adults with type 2 diabetes, behavioral weight loss interventions do not significantly reduce the long-term risk of cardiovascular disease events or all-cause mortality compared to standard care.Good
- Unintentional weight loss in type 2 diabetes is associated with a higher risk of all-cause mortality, whereas the association with intentional weight loss is unclear.Moderate
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
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