Mixed
General obesity (BMI ≥ 30 kg/m²) significantly increases the risk of cardiovascular and all-cause mortality across all glucose tolerance statuses (normoglycemia, pre-diabetes, and type 2 diabetes), regardless of glycemic control.
Maintaining a healthy weight is crucial for longevity, regardless of whether you have diabetes, pre-diabetes, or normal blood sugar. Obesity significantly raises your risk of dying from heart disease or other causes, so weight management should be a primary health goal.
We observed that being generally obese in comparison with non-obese increased the risk of CV and all-cause mortality in all glucose tolerance statuses
Why this rating
Large pooled cohort (n=18,184), long follow-up (16 years), multivariable adjusted, but observational design limits causal inference.
Source
The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis
Samaneh Asgari et al. · Diabetology & Metabolic Syndrome · 2024
DOI 10.1186/s13098-023-01253-0
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- Central adiposity (high waist circumference) is a significant independent risk factor for incident cardiovascular disease and all-cause mortality in individuals with normal glucose tolerance (NGT).Good
- General obesity does not significantly increase the risk of incident cardiovascular disease (CVD) events in individuals with type 2 diabetes, although it does increase mortality risk.Moderate
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