Mixed
General obesity does not significantly increase the risk of incident cardiovascular disease (CVD) events in individuals with type 2 diabetes, although it does increase mortality risk.
For people with diabetes, managing weight is less about preventing heart attacks and more about preventing death from any cause. While obesity doesn't significantly increase CVD risk in diabetics, it does increase mortality risk, so weight management remains important.
while considering CVD events, only among individuals with T2DM, the presence of general obesity was associated with marginally significant higher risk [1.19 (0.98–1.43); p-value = 0.07].
Why this rating
Large pooled cohort, but the finding is marginally significant (p=0.07) and may be influenced by confounding.
Source
The impact of obesity on different glucose tolerance status with incident cardiovascular disease and mortality events over 15 years of follow-up: a pooled cohort analysis
Samaneh Asgari et al. · Diabetology & Metabolic Syndrome · 2024
DOI 10.1186/s13098-023-01253-0
More from this paper
- General obesity (BMI ≥ 30 kg/m²) significantly increases the risk of cardiovascular and all-cause mortality across all glucose tolerance statuses (normoglycemia, pre-diabetes, and type 2 diabetes), regardless of glycemic control.Good
- Central adiposity (high waist circumference) is a significant independent risk factor for incident cardiovascular disease and all-cause mortality in individuals with normal glucose tolerance (NGT).Good
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