Mixed
High anabolic responders to resistance training exhibit greater baseline mitochondrial volume (citrate synthase activity) than low responders, suggesting mitochondrial capacity may facilitate muscle hypertrophy.
If you are struggling to build muscle despite consistent training, your mitochondrial capacity might be a limiting factor. While resistance training doesn't always increase mitochondria, high 'responders' tend to have higher baseline levels. Focus on general cardiovascular health alongside lifting to support the energy demands of muscle growth.
Main effects of cluster (HI>LO, p=0.018, Cohen’s d=0.737)... were observed for citrate synthase activity... Greater mitochondrial volume in HI responders may have facilitated greater anabolism
Why this rating
Observational analysis of a subset of a previous trial; correlational, not causal.
Source
Peer Review #3 of "Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training (v0.2)"
Brad J. Schöenfeld · 2018
DOI 10.7287/peerj.5338v0.2/reviews/3
More from this paper
- Low anabolic responders to resistance training upregulate myofibrillar myozenin-1 (MYOZ1) protein levels, whereas high responders do not, suggesting MYOZ1 may serve as a biomarker for differential adaptation.Moderate
- Resistance training does not significantly alter myofibrillar or sarcoplasmic protein concentrations (densities) in either high or low anabolic responders over 12 weeks.Moderate
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