Research
Mixed
Low anabolic responders to resistance training upregulate myofibrillar myozenin-1 (MYOZ1) protein levels, whereas high responders do not, suggesting MYOZ1 may serve as a biomarker for differential adaptation.
This finding is primarily for researchers. For trainees, it suggests that 'low responders' might be using different molecular pathways (like MYOZ1) to adapt compared to 'high responders'. There is no direct training intervention based on this yet.
ModerateQualifiesMEDIUM confidence
POST myofibrillar myozenin-1 protein levels were up-regulated in the LO cluster... within-group LO increase p=0.025, Cohen’s d = 0.691
Why this rating
Observational; requires mechanistic validation as stated by authors.
Source
Peer Review #3 of "Skeletal muscle mitochondrial volume and myozenin-1 protein differences exist between high versus low anabolic responders to resistance training (v0.2)"
Brad J. Schöenfeld · 2018
DOI 10.7287/peerj.5338v0.2/reviews/3
rct · n=25
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High anabolic responders to resistance training exhibit greater baseline mitochondrial volume (citrate synthase activity) than low responders, suggesting mitochondrial capacity may facilitate muscle hypertrophy.Moderate
- Resistance training does not significantly alter myofibrillar or sarcoplasmic protein concentrations (densities) in either high or low anabolic responders over 12 weeks.Moderate
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