Mixed
Chronic low-grade inflammation (inflammaging) is a fundamental endogenous driver of aging, creating a vicious cycle with cellular senescence that leads to organ dysfunction and age-related diseases.
Aging is closely linked to chronic, low-grade inflammation. While this paper is a mechanistic review, the implication is that strategies reducing systemic inflammation may support healthy aging. Focus on lifestyle factors known to modulate inflammation, such as regular physical activity, adequate sleep, and a nutrient-dense diet, as these are foundational to managing 'inflammaging'.
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases... Therefore, inflammation has been recognized as an endogenous factor in aging, and the elimination of inflammation could be a potential strategy for anti-aging.
Why this rating
Review article citing numerous primary studies across multiple cell types and organs.
Source
Inflammation and aging: signaling pathways and intervention therapies
Xia Li et al. · Signal Transduction and Targeted Therapy · 2023
DOI 10.1038/s41392-023-01502-8
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- Immunosenescence, characterized by a decline in immune cell function and an increase in pro-inflammatory cytokine secretion, impairs the clearance of senescent cells and pathogens, exacerbating aging.Strong
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