Research
Mixed
Senescent cells secrete pro-inflammatory factors (SASP) that drive further senescence in neighboring cells and impair immune function, creating a self-perpetuating cycle of tissue damage.
The accumulation of senescent cells contributes to tissue aging. While senolytics (drugs that clear senescent cells) are in development, current practical steps involve supporting the body's natural clearance mechanisms through healthy lifestyle habits that reduce cellular stress.
StrongSupportsHIGH confidence
Factors secreted by senescent cells, known as the senescence-associated secretory phenotype (SASP), promote chronic inflammation and can induce senescence in normal cells.
Why this rating
Well-established concept in the field, supported by extensive citations in the review.
Source
Inflammation and aging: signaling pathways and intervention therapies
Xia Li et al. · Signal Transduction and Targeted Therapy · 2023
narrative_reviewCited 1,228×
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